Premium
IC‐P‐194: DETECTION OF INCREASED MAGNETIC SUSCEPTIBILITIES IN THE CEREBRAL CORTEX IN PATIENTS WITH ALZHEIMER'S DISEASE: COMPARISON OF QUANTITATIVE SUSCEPTIBILITY MAPPING BETWEEN CONVENTIONAL AND BRAIN SURFACE CORRECTION METHOD
Author(s) -
Yamaguchi Akinori,
Kudo Kohsuke,
Sato Ryota,
Kawata Yasuo,
Udo Niki,
Matsushima Masaaki,
Yabe Ichiro,
Shirai Toru,
Ochi Hisaaki,
Bito Yoshitaka
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2261
Subject(s) - quantitative susceptibility mapping , voxel , putamen , white matter , orbitofrontal cortex , nuclear medicine , nuclear magnetic resonance , magnetic resonance imaging , medicine , neuroscience , psychology , radiology , prefrontal cortex , physics , cognition
progression among NC subjects (diagnostic conversion: HR1⁄4.84, p1⁄4.58; memory decline: b1⁄4-.01, p1⁄4.97; EF decline: b1⁄4-.05, p1⁄4.88; see Figure 2 for a visual representation). Conclusions:These results support hypothetical models proposing accelerated cognitive decline in individuals with high CR once clinical symptoms have emerged. The absence of such an effect among NC subjects suggests that the manifestation of CR is different across disease stages. Incorporating measures of CR in a clinical setting may contribute to a more accurate prognosis in symptomatic stages of AD.