IC‐P‐188: HYBRID SEQUENCE AND ANALYSIS OF T1‐WEIGHTED IMAGING AND QUANTITATIVE SUSCEPTIBILITY MAPPING FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE | Zendy

Sato Ryota | Zendy; Kudo Kohsuke | Zendy; Kawata Yasuo | Zendy; Udo Niki | Zendy; Matsushima Masaaki | Zendy; Yabe Ichiro | Zendy; Yamaguchi Akinori | Zendy; Shirai Toru | Zendy; Bito Yoshitaka | Zendy; Ochi Hisaaki | Zendy

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IC‐P‐188: HYBRID SEQUENCE AND ANALYSIS OF T1‐WEIGHTED IMAGING AND QUANTITATIVE SUSCEPTIBILITY MAPPING FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE

Author(s) -

Sato Ryota,

Kudo Kohsuke,

Kawata Yasuo,

Udo Niki,

Matsushima Masaaki,

Yabe Ichiro,

Yamaguchi Akinori,

Shirai Toru,

Bito Yoshitaka,

Ochi Hisaaki

Publication year - 2018

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2018.06.2255

Subject(s) - quantitative susceptibility mapping , susceptibility weighted imaging , nuclear medicine , flip angle , gradient echo , alzheimer's disease , medicine , weighting , cognitive impairment , magnetic resonance imaging , nuclear magnetic resonance , pathology , radiology , disease , physics

data, DM was not associated with PiB binding but was associated with FDG uptake (Figure) in a bilateral posterior cingulate cluster (voxels 1⁄4 948, Tmax 1⁄4 4.42, Pvoxel <.001, x, y, z 1⁄4 6, -22, 28). Conclusions: A disease marker for AD derived from routine T1 MRI scans outperforms CSF measures for tracking risk for disease progression in midlife. Such measures have great promise for facilitating broad-based early detection of AD.

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