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IC‐P‐188: HYBRID SEQUENCE AND ANALYSIS OF T1‐WEIGHTED IMAGING AND QUANTITATIVE SUSCEPTIBILITY MAPPING FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE
Author(s) -
Sato Ryota,
Kudo Kohsuke,
Kawata Yasuo,
Udo Niki,
Matsushima Masaaki,
Yabe Ichiro,
Yamaguchi Akinori,
Shirai Toru,
Bito Yoshitaka,
Ochi Hisaaki
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2255
Subject(s) - quantitative susceptibility mapping , susceptibility weighted imaging , nuclear medicine , alzheimer's disease , flip angle , gradient echo , weighting , nuclear magnetic resonance , dementia , medicine , magnetic resonance imaging , pathology , radiology , disease , physics
data, DM was not associated with PiB binding but was associated with FDG uptake (Figure) in a bilateral posterior cingulate cluster (voxels 1⁄4 948, Tmax 1⁄4 4.42, Pvoxel <.001, x, y, z 1⁄4 6, -22, 28). Conclusions: A disease marker for AD derived from routine T1 MRI scans outperforms CSF measures for tracking risk for disease progression in midlife. Such measures have great promise for facilitating broad-based early detection of AD.