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IC‐P‐187: CORTICAL T1‐W/T2‐W RATIO VALUES ARE HIGHER IN ALZHEIMER'S DISEASE COMPARED TO CONTROLS
Author(s) -
Pelkmans Wiesje,
Dicks Ellen,
Barkhof Frederik,
Scheltens Philip,
Flier Wiesje M.,
Tijms Betty M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2254
Subject(s) - dementia , medicine , pathological , nuclear medicine , myelin , pathology , disease , central nervous system
data, DM was not associated with PiB binding but was associated with FDG uptake (Figure) in a bilateral posterior cingulate cluster (voxels 1⁄4 948, Tmax 1⁄4 4.42, Pvoxel <.001, x, y, z 1⁄4 6, -22, 28). Conclusions: A disease marker for AD derived from routine T1 MRI scans outperforms CSF measures for tracking risk for disease progression in midlife. Such measures have great promise for facilitating broad-based early detection of AD.