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IC‐P‐178: COMPARING HIPPOCAMPAL EFFECT SIZE BETWEEN ALZHEIMER'S DISEASE AND HEALTHY CONTROLS USING OLDER AND NEWER VERSIONS OF SPM AND FREESURFER
Author(s) -
Deardorff Rachael,
Groot Colin,
Zalewski Kody,
Ossenkoppele Rik,
Donald Christine Mac,
West John D.,
Mormino Beth C.,
Saykin Andrew J.,
Crane Paul K.,
Risacher Shan L.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2245
Subject(s) - hippocampal formation , neuroimaging , voxel , voxel based morphometry , alzheimer's disease neuroimaging initiative , reproducibility , psychology , medicine , neuroscience , audiology , nuclear medicine , magnetic resonance imaging , cognitive impairment , white matter , cognition , radiology , mathematics , statistics
superior longitudinal fasciculus and external capsule were no longer statistically different. Conclusions: DBSI is an MRI-based approach to assess neuroinflammation. Referencing to a normal population provides a means of anchoring the signal so as to determine ‘abnormal’ CR levels as a measure of neuroinflammation, independent of effects of normal aging. This analysis strategy should be extended to grey matter.