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IC‐P‐169: HYPERFUNCTIONAL CONNECTIVITY ASSOCIATED WITH GENETIC RISKS OF DEMENTIA
Author(s) -
Su Li,
Li Zhi,
Ritchie Craig W.,
Ritchie Karen,
Waldman Adam,
Wells Katie,
O'Brien John T.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2236
Subject(s) - dementia , family history , medicine , audiology , neuroimaging , dementia with lewy bodies , postcentral gyrus , psychology , psychiatry , somatosensory system , disease
possible ePVS if [FRANK4>0.95, DIFF5>.15*i]. For T2, [FRANK4<0.95, DIFF5<.15*i]. Each 5mm cluster was further subjected to morphological filtering on linearity and width; linearity was calculated as percent explained variance of the primary eigenvector of each cluster, width was calculated as the intersection of planes normal to that vector and the edges of each cluster.Results: There was a high correspondence between visual ePVS counts and mMAPS, T1, and T2 counts over all subjects; all methods were significantly correlated over repeated measurements in the single visually rated slice and over the whole brain (Figure 2). SNR and CNR of segmented ePVS using single sequence methods and all statistical results are available in Table 1. Conclusions: While consultation of several sequence weightings is preferred to ensure that a putative ePVS is isointense to CSF on all sequences, the single sequence automated method of segmentation, based largely on refined morphological constraints, is highly correlated to expert visual counts and previously published automated methods. This method may be applicable to large single sequence datasets such as ADNI, and would add valuable information regarding location and morphology of ePVS.