Premium
IC‐P‐150: HYPOXIA DURING SLEEP IS ASSOCIATED WITH HIPPOCAMPAL VOLUME IN COGNITIVELY UNIMPAIRED ADULTS
Author(s) -
Taylor Chase E.,
Sprecher Kate E.,
Vogt Nicholas M.,
Derynda Brittany R.,
Shouel Heather L.,
Oh Jennifer M.,
Jones Stephanie G.,
Riedner Brady A.,
Bazalakova Mihaela H.,
Plante David T.,
Johnson Sterling C.,
Asthana Sanjay,
Benca Ruth M.,
Bendlin Barbara B.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2216
Subject(s) - medicine , quartile , hypoxemia , polysomnography , hippocampal formation , respiratory disturbance index , cardiology , anesthesia , apnea , confidence interval
between annual rates of metabolic decline in each area with higher fasting blood glucose levels. Conclusions:Female sex is a risk factor for development of dementia for reasons that are incompletely understood. Verbal memory performance is higher in women than men, as is metabolism within the frontal and medial temporal regions involved in mediating it. Both medial temporal and Broca’s areas tended to metabolically decline faster in women with MCI than in men, and that decline in women (but not men) was accelerated by higher fasting blood glucose levels. The observed changes in regional cerebral metabolism may thus point to exacerbating interactions between known risk factors for Alzheimer’s disease development, and the possibility that maintaining normoglycemic status may be of particular benefit among women with elevated risk for developing dementia.