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IC‐P‐145: NON‐AMNESTIC PHENOTYPES OF ALZHEIMER'S DISEASE, EARLY AGE OF ONSET AND APOE GENOTYPE ARE ASSOCIATED WITH TAU, NOT Aβ‐PET
Author(s) -
La Joie Renaud,
Visani Adrienne,
Lesman-Segev Orit H.,
Bourakova Viktoriya,
Baker Suzanne L.,
Janabi Mustafa,
Miller Zachary A.,
O'Neil James P.,
Perry David,
Pham Julie,
Rosen Howard J.,
Miller Bruce L.,
Jagust William J.,
Rabinovici Gil D.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2211
Subject(s) - primary progressive aphasia , clinical dementia rating , standardized uptake value , positron emission tomography , medicine , white matter , atrophy , pathology , psychology , dementia , nuclear medicine , neuroscience , magnetic resonance imaging , frontotemporal dementia , disease , radiology
Figure 3. APOE-ε4 is specifically associated with increased Flortaucipir SUVR in the medial temporal lobe. Left. Voxelwise ANCOVA analyses of Flortaucipir, comparing 41 ε4 carriers (32 ε3/ε4 + 9 ε4/ε4) to 35 ε4 non-carriers (34 ε3/ε3 + 1 ε2/ε3); two patients carrying ε2/ε4 were not included in this analysis. No significant cluster was found in the ε4 carriers < ε4 non-carriers contrast, even at the uncorrected p<0.001 threshold. Right. Confirmation of the voxelwise finding based on the average Flortaucipir SUVR extracted from the medial temporal lobe in native space using FreeSurfer (combining hippocampus, amygdala, and entorhinal cortex). Bars indicate median and quartiles within each group and the effect size is given as Cohen’s d (with 95% confidence interval) Renaud La Joie, Adrienne Visani, Orit H. Lesman-Segev, Viktoriya Bourakova, Suzanne L. Baker, Mustafa Janabi, Zachary A. Miller, James P. O’Neil, David Perry, Julie Pham, Howard J. Rosen, Bruce L. Miller, William J. Jagust, Gil D. Rabinovici, University of California, San Francisco, San Francisco, CA, USA; University of California San Francisco, San Francisco, CA, USA; Lawrence Berkeley National Laboratory, Berkeley, CA, USA; Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; University of California San Francisco, San Francisco, CA, USA; University of California Berkeley, Berkeley, CA, USA. Contact e-mail: renaud.lajoie@ gmail.com