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IC‐P‐140: TAU ACCUMULATION AND MEMORY DECLINE ARE MORE CLOSELY RELATED TO STRIATAL THAN CORTICAL AMYLOIDOSIS IN INDIVIDUALS WITH EARLY‐ONSET AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE
Author(s) -
Hanseeuw Bernard J.,
Lopera Francisco,
Sperling Reisa A.,
Norton Daniel,
Guzman-Velez Edmarie,
Baena Ana,
Schultz Aaron P.,
Gatchel Jennifer R.,
Chen Kewei,
Reiman Eric M.,
Johnson Keith A.,
Quiroz Yakeel T.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2206
Subject(s) - psen1 , neuroscience , amyloid (mycology) , dementia , entorhinal cortex , putamen , alzheimer's disease , psychology , population , amyloidosis , hippocampus , disease , medicine , pathology , amyloid precursor protein , environmental health
GDS-slope, amyloid, GDS-slope X amyloid, and the covariates above. Results:In the model with baseline GDS, sex (p1⁄40.0005; females with higher scores), higher age (p<0.0001), lower education (p<0.0001), and amyloid X time (p1⁄40.0088; greater amyloid associated with greater PACC decline) were significant, but baseline GDS did not predict PACC decline. In the model with GDS-slope, higher age (p<0.0001), lower education (p1⁄40.03) and GDS-slope X amyloid (p1⁄40.0002) significantly predicted PACC decline, such that increasing GDS scores with baseline amyloid were associated with greater PACC decline. In secondary analyses holding time and all other predictors constant, longitudinally increasing GDS predicted decreasing PACC in those with amyloid levels above 1.10. Conclusions:Results suggest that worsening depressive symptoms in the setting of elevated amyloid are associated with cognitive decline. While future work is needed to determine causality, findings support the potential prognostic utility of depressive symptoms in identifying older adults at risk for cognitive decline and AD.