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IC‐P‐139: LONGITUDINAL DEPRESSIVE SYMPTOMS AND CORTICAL AMYLOID ARE ASSOCIATED WITH COGNITIVE DECLINE IN OLDER ADULTS
Author(s) -
Gatchel Jennifer R.,
Rabin Jennifer S.,
Buckley Rachel F.,
Locascio Joseph J.,
Quiroz Yakeel T.,
Vannini Patrizia,
Amariglio Rebecca,
Rentz Dorene M.,
Blacker Deborah,
Johnson Keith A.,
Donovan Nancy J.,
Sperling Reisa A.,
Marshall Gad A.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2205
Subject(s) - geriatric depression scale , longitudinal study , medicine , depression (economics) , amyloid (mycology) , cognitive decline , depressive symptoms , cognition , alzheimer's disease , disease , oncology , gerontology , dementia , pathology , psychiatry , economics , macroeconomics
Figure 1. Higher GDS predicts worsening PACC, holding time and all other predictors constant, in thosewith elevated amyloid levels (greater than 1.10) Figure 1. PACC predicted by longitudinal GDS, holding time and all other predictors constant. Amyloid (Pittsburgh Compound B PET) levels represent one standard deviation below the mean of the sample (1.0), mean of the sample (1.2), one standard deviation above the mean (1.4), and the 95 percentile (1.6, given the positive skew). Time, GDS, age, and education are set at means; sex1⁄4female. PACC1⁄4 preclinical Alzheimer’s Disease Cognitive Composite; GDS1⁄4 Geriatric Depression Scale. Poster Presentations: Saturday, July 21, 2018 P116