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IC‐P‐134: INTERPLAY BETWEEN BASELINE AND LONGITUDINAL CHANGE IN NEUROIMAGING MARKERS OF AMYLOID DEPOSITION AND NEURODEGENERATION ACROSS THE ALZHEIMER'S DISEASE SPECTRUM
Author(s) -
Bejanin Alexandre,
Arenaza-Urquijo Eider M.,
Flores Robin,
Tomadesso Clémence,
Sherif Siya,
Landeau Brigitte,
Chetelat Gael
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2200
Subject(s) - neuroimaging , temporal lobe , alzheimer's disease neuroimaging initiative , white matter , brain size , pittsburgh compound b , medicine , psychology , dementia , neuroscience , cardiology , magnetic resonance imaging , disease , radiology , epilepsy
modality associations between baseline and longitudinal change of each imaging modality. Linear mixed effects analyses were performed using R (nlme package) to estimate the effect of baseline on rate of change over time, whilst incorporating the longitudinal nature of the data by including within-person variation as random effects. Age at baseline and sex were included as covariates in all models. Models can be summarized as follow: Intra-modality relationship/ (Modalityl Annual Rate of Change)Region i w (Baseline Modalityl)Region j + Age + Sex + (1 j Subject) Inter-modality relationship/ (Modalityl Annual Rate of Change)Region i w (Baseline Modality2)Region js + Age + Sex + (1 j Subject) whereModality corresponds to volume, FDGor AV45-SUVR, and Region i and Region j represent one bilateral ROIs of the Harvard-Oxford structural atlas. Note that on the heatmaps, ROIs are shown in the same order for xand y-axis. Therefore, the upper diagonal represents the relationships when the Figure 2. regions showing GM atrophyi n NC-p (in green), NC-s (in blue), and group-interaction (in red). Poster Presentations: Saturday, July 21, 2018 P111