IC‐P‐134: INTERPLAY BETWEEN BASELINE AND LONGITUDINAL CHANGE IN NEUROIMAGING MARKERS OF AMYLOID DEPOSITION AND NEURODEGENERATION ACROSS THE ALZHEIMER'S DISEASE SPECTRUM

modality associations between baseline and longitudinal change of each imaging modality. Linear mixed effects analyses were performed using R (nlme package) to estimate the effect of baseline on rate of change over time, whilst incorporating the longitudinal nature of the data by including within-person variation as random effects. Age at baseline and sex were included as covariates in all models. Models can be summarized as follow: Intra-modality relationship/ (Modalityl Annual Rate of Change)Region i w (Baseline Modalityl)Region j + Age + Sex + (1 j Subject) Inter-modality relationship/ (Modalityl Annual Rate of Change)Region i w (Baseline Modality2)Region js + Age + Sex + (1 j Subject) whereModality corresponds to volume, FDGor AV45-SUVR, and Region i and Region j represent one bilateral ROIs of the Harvard-Oxford structural atlas. Note that on the heatmaps, ROIs are shown in the same order for xand y-axis. Therefore, the upper diagonal represents the relationships when the Figure 2. regions showing GM atrophyi n NC-p (in green), NC-s (in blue), and group-interaction (in red). Poster Presentations: Saturday, July 21, 2018 P111