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IC‐P‐133: STRUCTURAL ABNORMALITIES OF LIMBIC SYSTEM SERVE AS POTENTIAL BIOMARKERS FOR THE ONSET AND PROGRESS OF MILD COGNITIVE IMPAIRMENT
Author(s) -
Yang Caishui,
Fan Jialing,
Wang Wenxiao,
Xia Jianan,
Li Xin,
Li He,
Zhang Zhanjun
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2199
Subject(s) - medicine , neuropsychology , population , cognitive impairment , dementia , cognition , pediatrics , audiology , disease , psychiatry , environmental health
ship with hippocampal and parahippocampal subregions is less clear. We investigate 1) the association of age with MTL subregion volumes, 2) the association of white matter hyperintensity (WMH) volume, a proxy for CVD, and MTL subregions, 3) the degree to which age effects on MTL atrophy are explained by WMHs, and 4) the association of age, WMHs and MTL subregions with memory in cognitively normal older adults. Methods:Hippocampal and parahippocampal subregion volumes were obtained using the Automated Segmentation for Hippocampal Subfields (ASHS) software and WMH volume using an automated method in 69 cognitively normal older adults (73.267.7 years; 37.8% men) from the Penn Alzheimer’s Disease Center cohort. Delayed recall on the Craft story task was obtained. Partial correlations were performed with intracranial volume, gender and education for delayed recall as covariates. Results: 1) Age was significantly associated with all MTL subregions, and at a trend level with Brodmann area (BA) 35 (Table 1). 2) A significant association was found between WMHs and cornu ammonis (CA) 1, subiculum and entorhinal cortex (ERC) (Table 2). 3) After correcting for WMHs, the association with age remained significant for most regions, except DG and the parahippocampal cortex; while still significant for CA1, the correlation was considerably reduced when correcting for WMHs. 4) Delayed recall was significantly associated with age and several MTL subregions (CA1 was strongest), and was at trend level with WMH volume (Table 3). The association with CA1, but not other MTL subregions, remained significant after additionally correcting for age and WMHs. Conclusions:These preliminary results indicate that while WMHs may partly explain age-related atrophy in some MTL subregions, several regions were still significantly associated with age after correcting for WMHs, especially those regions that are associated with early neurofibrillary pathology, such as CA1, ERC and BA35. IC-P-133 STRUCTURAL ABNORMALITIES OF LIMBIC SYSTEM SERVE AS POTENTIAL BIOMARKERS FOR THE ONSETAND PROGRESS OF MILD COGNITIVE IMPAIRMENT Caishui Yang, Jialing Fan, WenxiaoWang, Jianan Xia, Xin Li, He Li, Zhanjun Zhang, State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China. Contact e-mail: yang_1991@mail.bnu.edu.cn