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IC‐P‐125: THE MIDBRAIN IS THE OPTIMAL INTENSITY NORMALIZATION REGION FOR FDG‐PET STUDIES OF NORMAL AGING
Author(s) -
Nugent Scott,
Croteau Etienne,
Potvin Olivier,
Castellano Christian-Alexandre,
Cunnane Stephen,
Duchesne Simon
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2191
Subject(s) - midbrain , normalization (sociology) , nuclear medicine , positron emission tomography , pons , healthy aging , medicine , central nervous system , gerontology , sociology , anthropology
spin labeling (ASL) sequence on a 3 Tesla scanner. ASL analysis was performed using SPM12. Results:MCAv reactivity was 1.90 6 0.15 cm/s/mmHg and CVCi reactivity was 0.017 6 0.001 cm/ s/mmHg. Resting global cerebral perfusion was 35.0 6 1.1 ml/ 100g/min. There was no significant relationship between MCAv reactivity and resting global cerebral perfusion (r 1⁄4 0.20, p 1⁄4 0.21); however there was a positive relationship between CVCi reactivity and resting global cerebral perfusion (r 1⁄4 0.31, p 1⁄4 0.05). Conclusions:These results indicate that when blood pressure is accounted for, cerebral perfusion at rest is related to cerebrovascular vasodilatory function in healthy adults. This suggests that individuals with higher cerebral perfusion at rest have a more robust response to a vasoactive stimulus such as hypercapnia, indicating better function of the cerebral vessels. Future studies are planned to evaluate the role of cerebral perfusion and cerebral vessel function in the development of AD.