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IC‐P‐122: THE NORMAL AGING BRAIN COLLECTION AMSTERDAM (NABCA): A COMPREHENSIVE COLLECTION OF POSTMORTEM IMAGING, NEUROPATHOLOGICAL AND MORPHOMETRIC DATASETS
Author(s) -
Jonkman Laura E.,
Galis Yvon,
Kaai Eliane,
Weerd Louise,
Pouwels Petra JW.,
Barkhof Frederik,
Rozemuller Annemieke M.,
Geurts Jeroen JG.,
Berg Wilma DJ.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2188
Subject(s) - white matter , fluid attenuated inversion recovery , medicine , hyperintensity , cerebellar hemisphere , diffusion mri , pathology , neuroimaging , magnetic resonance imaging , nuclear medicine , radiology , psychiatry
measured by a surface-based method. To study the association of cardiometabolic risk factors with cortical thickness, data were analyzed using multiple linear regression after adjusting possible confounders and their interaction with aging. Results: In multivariate analysis, women showed that HTN was negatively associated with cortical thickness, globally and regionally. DMwas also negatively associated with cortical thickness in the temporal region. There were interactive effects between age and obesity on cortical thickness throughout the entire cortex (b 1⁄4 -0.320 w -0.010, p < 0.05), suggesting that the slope of the cortical thickness versus age plot was steeper in women with obesity than in women with normal weight. On the other hand, men showed that underweight was negatively associated with cortical thickness throughout the entire cortex (b1⁄4 -2.656w -0.073, p< 0.05). Conclusions:Women were more vulnerable to the cardiometabolic risk factors than men. These findings could suggest new clues to why women are more susceptible to dementia. Different strategies may need to be adjusted for the prevention of dementia according to their cardiometabolic risk factors and gender.