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IC‐P‐120: MEDIAL TEMPORAL LOBE ATROPHY SCALE: NORMATIVE VALUES FOR ITALIAN POPULATION
Author(s) -
Ramusino Matteo Cotta,
Altomare Daniele,
Costa Alfredo,
Festari Cristina,
Frisoni Giovanni B.,
Boccardi Marina
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2186
Subject(s) - atrophy , temporal lobe , normative , psychology , population , percentile , magnetic resonance imaging , percentile rank , boston naming test , medicine , audiology , neuropsychology , pathology , neuroscience , radiology , cognition , statistics , philosophy , mathematics , environmental health , epistemology , epilepsy
Matteo Cotta Ramusino, Daniele Altomare, Alfredo Costa, Cristina Festari, Giovanni B. Frisoni, Marina Boccardi, Center for Cognitive and Behavioral Disorders, C. Mondino National Neurological Institute, Pavia, Italy; Istituto di Ricovero e Cura a Carattere Scientifico, Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; University of Brescia, Brescia, Italy; University of Geneva, Geneva, Switzerland. Contact e-mail: giovanni.frisoni@gmail.com Background:The medial temporal lobe atrophy scale (MTA) is a 0to-4 visual rating scale for assessing the degree of hippocampal atrophy. Despite it is widely used due to its ease of employment, to date normative values are still missing. Methods: A trained rater, showing an excellent inter-rater agreement (ICC1⁄40.892; 95% CI: 0.723-0.958) with an expert rater, assessed coronal-T1 MR scans of the 936 cognitively healthy persons from the Italian Brain Normative Archive Study, and provided MTA scores for both hemispheres. Subjects (age: mean6SD: 50.2614.7; range: 2084) were selected retrospectively for having MMSE>26 and/or CDR1⁄40. We provided the normative data by age decades based on the percentile distribution, and investigated the correlation between MTA scores and APOE genotype, when the latter was available (56.3%). Results: MTA score (mean6SD: 0.660.7 for both sides) had a skewed distribution, half of the sample scoring 0 (on the right: n1⁄4480, 51.3%; on the left: n1⁄4475, 50.7%), and less than 10% scoring more than 1 (on the right: n1⁄471, 7.6%; on the left: n1⁄465, 6.9%). No significant difference was observed between sides in MTA scores (p1⁄41.000). The 90 percentile cut-off of the age-specific distribution increased from 1 (at age 20-59) to 2 (at age 60-79) and then up to 4 for subjects over 80s (Figure). No significant difference was observed between APOε4 carriers and noncarriers, neither in the whole sample (p1⁄40.23 right; p1⁄40.88 left), nor in the subsets over 60 (p1⁄40.96 right; p1⁄40.72 left). Conclusions: This study provides the first normative values for MTA in the general population. According to the literature, our data suggest the presence of different age-related cut-offs and, thus, the need to consider different thresholds depending on age. References: 1. Scheltens P et al. Atrophy of medial temporal lobes on MRI in "probable" Alzheimer’s disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992; 55(10):967-972. 2. Galluzzi S et al. The Italian Brain Normative Archive of structural MR scans: norms for medial temporal atrophy and white matter lesions. Aging Clin Exp Res. 2009; 21(4-5):266-276.