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IC‐P‐109: THE COGNITIVE CHANGE INDEX IS ASSOCIATED WITH TAU DEPOSITION ON [ 18 F]FLORTAUCIPIR
Author(s) -
Risacher Shan L.,
Tallman Eileen F.,
West John D.,
McDonald Brenna C.,
Unverzagt Fred W.,
Apostolova Liana G.,
Farlow Martin R.,
Saykin Andrew J.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2175
Subject(s) - psychology , cognition , temporal lobe , cognitive impairment , nuclear medicine , developmental psychology , medicine , psychiatry , epilepsy
region (whole cerebellum for FBP, cerebellar grey matter for FBB, cerebellar crus for FTP). SUVR values from the cerebral cortex (for amyloid measures) and the MTL (includes entorhinal cortex, fusiform, and parahippocampal gyri; for FTP) were extracted. Entorhinal cortex (EC) thickness was determined using Freesurfer v5.1. Linear regression models were completed to determine whether contrast sensitivity and UPSIT total score together predict amyloid (z-scored relative to ADNI CN), tau, and atrophy better than either measure alone, covaried for age as needed. Results:In combination, the visual and olfactory measures predicted amyloid, tau, and EC thickness, with poorer performance associated with more amyloid and tau and thinner EC (p<0.05; Table 1, Figure 1A, 2A, 3A). Lower visual contrast sensitivity alone predicted higher tau (p<0.001; Figure 2B), while lower UPSIT score alone predicted a thinner EC (p1⁄40.021, Figure 3C). Conclusions: In general, the combination of both a visual and an olfactory measure showed a better prediction of amyloid, tau, and neurodegeneration. These findings suggest that multi-modal vs single modality sensory assessment may provide a better estimation of AD-related pathology during preclinical and prodromal disease stages.