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IC‐P‐100: USING MULTIMODAL IMAGING BIOMARKERS TO PREDICT COGNITIVE STATUS IN A COMMUNITY‐DWELLING OLDER ADULT COHORT
Author(s) -
Lockhart Samuel N.,
Hoscheidt Siobhan M.,
Fatima Hudaisa,
Sanderlin Ashley H.,
Whitlow Christopher T.,
Jung Youngkyoo,
Craft Suzanne
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2164
Subject(s) - hyperintensity , medicine , fluid attenuated inversion recovery , cohort , neuropsychology , psychology , effects of sleep deprivation on cognitive performance , precuneus , cognition , cardiology , audiology , magnetic resonance imaging , radiology , psychiatry
Background: Imaging biomarkers of cerebrovascular disease (CVD) and neurodegeneration may potentially reflect different underlying processes related to Alzheimer’s Disease (AD) pathology in late life. We sought to explore impacts of white matter hyperintensities (WMH, an index of CVD) and ADsignature cortical thickness on cognitive status in a community-dwelling older adult cohort from the Wake Forest Alzheimer’s Disease Clinical Core (ADCC). Methods: N1⁄4130 ADCC participants (Table 1) underwent brain MRI (T1, FLAIR) and neuropsychological assessment. Participants were determined to be cognitively normal (CN) or have mild cognitive impairment