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IC‐P‐098: CORTICAL THICKNESS ATROPHY IN THE TRANSENTORHINAL CORTEX IN MILD COGNITIVE IMPAIRMENT
Author(s) -
Kulason Sue,
Tward Daniel J.,
Sicat Chelsea S.,
Bakker Arnold,
Gallagher Michela,
Albert Marilyn S.,
Miller Michael
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2162
Subject(s) - entorhinal cortex , atrophy , white matter , neuroimaging , neuroscience , cerebral cortex , cognition , cortex (anatomy) , psychology , gyrification , magnetic resonance imaging , medicine , pathology , hippocampus , radiology
Figure 2. Association between AD-pattern hypometabolism and global cognition by CR Note: AD, Alzheimer’s disease; AD-CMglu, cerebral metabolism of glucose of AD-signature regions; CERAD TS, Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet. al., 2005)). Global Ab deposition, AD-pattern hypometabolism and AD-signature cortical thickness were assessed as in vivo AD pathologies. Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD) total score (TS) was used as a cognitive performance measure. We performed generalized linear model analysis with CR proxies, in vivo AD pathologies and CR x in vivo AD pathology interaction term as independent variables, and CERAD TS as a dependent variable. Results: Only KART IQ moderated the relation of AD-signature cortical thickness to CERAD TS (p< .01). KART IQ (p< .001), education (p 1⁄4 .01) and CA (p 1⁄4 .008) moderated the relation of AD-pattern hypometabolism to CERAD TS, while occupational complexity showed trend level association (p1⁄4 .05). Any of the CR proxy measures did not moderate the association between global Ab deposition and CERAD TS. Conclusions: The findings indicate that premorbid IQ predicted by adult reading test was the most appropriate proxy measure for CR. Education and participation in lifetime CA may also be useful as a CR proxy.