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IC‐P‐095: CORTICAL CEREBRAL MICROINFARCTS PREDICT COGNITIVE DECLINE IN A MEMORY CLINIC POPULATION
Author(s) -
Hilal Saima,
Tan Chuen Seng,
Veluw Susanne J.,
Xu Xin,
Tan Boon Yeow,
Venketasubramanian Narayanaswamy,
Biessels Geert Jan,
Chen Christopher
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2159
Subject(s) - memory clinic , cognitive decline , montreal cognitive assessment , population , cognition , neuropsychology , medicine , stroke (engine) , dementia , confidence interval , cohort , effects of sleep deprivation on cognitive performance , gerontology , psychology , psychiatry , cognitive impairment , disease , mechanical engineering , environmental health , engineering
preserved baseline language and slower decline on attention. Correlations between baseline and follow-up (mean MRI-interval 1.560.8 years) factor expressions were r1⁄40.56, r1⁄40.77 and r1⁄40.91 (p<0.05), indicating that factor expressions were robust over time. Finally, there were no correlations between factor expressions, MMSE and whole-brain atrophy, suggesting that factor expressions are not predominantly reflecting clinical or biological disease progression. Conclusions: PCA patients displayed distinct and robust latent atrophy factors that were associated with specific cognitive deficits and longitudinal trajectories, mostly in line with established brain-behavior relationships. This approach highlights substantial phenotypical heterogeneity within the spectrum of PCA.