Premium
IC‐P‐084: EFFECTS OF AGE AND CSF MEASURES OF TAU ON MNEMONIC DISCRIMINATION OF OBJECTS AND SCENES IN MEDIAL TEMPORAL LOBE PATHWAYS
Author(s) -
Berron David,
Cardenas-Blanco Arturo,
Bittner Daniel,
Metzger Coraline D.,
Spottke Annika,
Heneka Michael,
Fließbach Klaus,
Schneider Anja,
Teipel Stefan J.,
Wagner Michael,
Speck Oliver,
Jessen Frank,
Düzel Emrah
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2148
Subject(s) - perirhinal cortex , retrosplenial cortex , precuneus , entorhinal cortex , temporal lobe , psychology , neuroscience , functional magnetic resonance imaging , parahippocampal gyrus , recognition memory , fusiform gyrus , temporal cortex , episodic memory , hippocampus , cognition , epilepsy
distinguished logopenic-PPA from agrammatic-PPA and semanticPPA, and the second represented a frontal-versus-temporal contrast that distinguished agrammatic-PPA and semantic-PPA. [F]AV1451 outperformed both FDG-PET and MRI when using two principal components. When considering three-to-seven principal components, [F]AV-1451 and FDG-PETwere comparable while both consistently outperformed MRI (Figure 2). Conclusions: [F]AV1451 binding characteristics differ across the PPA variants, and were excellent at distinguishing between variants. [F]AV-1451 was as good as or better than FDG-PET and MRI, suggesting that it may have clinical diagnostic utility in PPA.