IC‐P‐081: AMYLIN DYSHOMEOSTASIS: A NON‐AD PROCESS CONTRIBUTING TO AN AD PHENOTYPE

patients was 85.4%. In model 2, AD patients and FTD patients were classified with 90.2% accuracy. The accuracies in discriminating between FTD subtypes were 85.0%, 89.9%, 92.8% in model 3 to 5, respectively. Patterns of discriminative cortical regions were consistent with previous observations in some degree, although significantly influenced by the combination of groups compared. SvPPA group showed significant discriminative value in left temporal region whereas characteristic change in bilateral frontal region was observed in bvFTD group. When compared with svPPA group, nfvPPA group showed significant difference especially in bilateral temporal pole. By contrast, when compared with bvFTD group, discriminative regions of nfvPPA group mainly distributed over left frontal cortex. Conclusions:Our method therefore demonstrated high classification performance in distinguishing FTD subtypes from AD and normal controls, and also in further distinguishing FTD subtypes from each other, supporting the discriminative power of our method in diagnosis.