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IC‐P‐068: A POLYGENIC AD RISK SCORE PREDICTS AMYLOID ACCUMULATION OVER A 6‐YEAR INTERVAL IN COGNITIVELY INTACT OLDER ADULTS
Author(s) -
Gabel Silvy,
Schaeverbeke Jolien,
Adamczuk Katarzyna,
Van Laere Koen,
Dupont Patrick,
Van Broeckhoven Christine,
Sleegers Kristel,
Vandenberghe Rik
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2133
Subject(s) - pittsburgh compound b , confidence interval , medicine , apolipoprotein e , standardized uptake value , dementia , positron emission tomography , nuclear medicine , disease
campus-connectivity was associated with attenuated decreases in memory recall and MMSE, controlled for gender, site, education and hippocampal volume. Results:In the MC group, we found a significant interaction BDNFVal66MetxEYO on right hippocampus connectivity within the bilateral mediofrontal cortex (Figure 1A; voxel-wise p<0.005, FWE-cluster-corrected). That is, BDNFValcarriers exhibited an attenuated decline in hippocampus-mediofrontal connectivity during the course of AD when compared to BDNFMet-carriers (Figure 1B). In MC, lower right hippocampusmediofrontal connectivity was associated with attenuated decrease in delayed recall (p<0.05, Figure 1C) and MMSE scores (p<0.001). No effects were found in NC. Conclusions: The BDNFVal66Met-SNP moderates hippocampal connectivity decline in ADAD, where BDNFVal-carriage is associated with a relatively preserved hippocampal-mediofrontal connectivity that may ameliorate episodic memory impairment during AD.