IC‐P‐068: A POLYGENIC AD RISK SCORE PREDICTS AMYLOID ACCUMULATION OVER A 6‐YEAR INTERVAL IN COGNITIVELY INTACT OLDER ADULTS

campus-connectivity was associated with attenuated decreases in memory recall and MMSE, controlled for gender, site, education and hippocampal volume. Results:In the MC group, we found a significant interaction BDNFVal66MetxEYO on right hippocampus connectivity within the bilateral mediofrontal cortex (Figure 1A; voxel-wise p<0.005, FWE-cluster-corrected). That is, BDNFValcarriers exhibited an attenuated decline in hippocampus-mediofrontal connectivity during the course of AD when compared to BDNFMet-carriers (Figure 1B). In MC, lower right hippocampusmediofrontal connectivity was associated with attenuated decrease in delayed recall (p<0.05, Figure 1C) and MMSE scores (p<0.001). No effects were found in NC. Conclusions: The BDNFVal66Met-SNP moderates hippocampal connectivity decline in ADAD, where BDNFVal-carriage is associated with a relatively preserved hippocampal-mediofrontal connectivity that may ameliorate episodic memory impairment during AD.