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IC‐P‐056: POSTMORTEM 7T MRI FOR GUIDED HISTOLOGY AND TISSUE SEGMENTATION
Author(s) -
Lahna David,
Woltjer Randy,
Grinstead John,
Boespflug Erin L.,
Schwartz Daniel,
Kaye Jeffrey A.,
Rooney William D.,
Silbert Lisa C.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2121
Subject(s) - in vivo , magnetic resonance imaging , hyperintensity , histology , white matter , fixation (population genetics) , medicine , nuclear medicine , biomedical engineering , pathology , radiology , biology , population , microbiology and biotechnology , environmental health
MK6240 SUVRw [F]AZD4694 SUVR + age + gender + APOE + education. Results:The unique association between amyloidosis and NFTs was present in entorhinal cortex and PCC in CN; precuneus, PCC, and parahippocampal gyrus in MCI; ACC, entorhinal cortex, parahippocampal gyrus, and orbitofrontal cortex in AD. All groups showed the association in lateral temporal and middle frontal gyrus. Conclusions: Our results revealed both similar and different association patterns between amyloidosis andNFTs across AD stage. Most common association pattern was present at left lateral temporal cortex across all stages while the different association pattern moved from PCC, precuneus, to orbitofrontal cortex in CN, MCI, and AD, respectively. This corroborates the two pathologies spread from the posterior to anterior regions of the brain.