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IC‐P‐045: SIMILAR METABOLIC BRAIN CHARACTERISTICS OF DEMENTIA WITH LEWY BODIES AND PARKINSON'S DISEASE DEMENTIA
Author(s) -
Schindlbeck Katharina A.,
Rus Tomaž,
Tomše Petra,
Jensterle Luka,
Grmek Marko,
Kramberger Milica G.,
Pirtošek Zvezdan,
Tang Chris C.,
Eidelberg David,
Trošt Maja
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2109
Subject(s) - dementia with lewy bodies , dementia , parkinson's disease , lewy body , disease , pathological , medicine , psychology , central nervous system disease , pathology , neuroscience
significantly different between CNAß+ and EMCIAß+, but was significantly higher in CNAß+ than LMCIAß+ (p<0.001). D was significantly higher in EMCIAß+ than LMCI Aß+ (p<0.02). PC5, including visual, sensory-motor, and superior-temporal regions was associated with visuospatial and language function, while PC38, showing frontal interactions, was associated with executive function. Conclusions:Reconstructing FC with disease dependent components increases sensitivity to differences in connectivity across the AD spectrum and identifies functional subnetworks implicated in early stages of AD.