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IC‐P‐038: DIFFERENTIAL LONGITUDINAL POSTERIOR CINGULATE CORTEX CONNECTIVITY TRAJECTORIES IN NORMAL AGING, MCI AND AD
Author(s) -
Lee Briana E.,
Grabowski Thomas J.,
Madhyastha Tara
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2102
Subject(s) - posterior cingulate , default mode network , dementia , resting state fmri , alzheimer's disease , neuroscience , voxel , audiology , psychology , alzheimer's disease neuroimaging initiative , disease , cortex (anatomy) , medicine , cognition , radiology
AFNI’s 3dReHo. As data were not smoothed, we chose a conservative, uncorrected threshold of significance of p1⁄4.005 and k1⁄430 (240mm3). SPM12 was used to calculate two regression analyses, predicting ReHo from cumulative SBP and DBP adjusted for age, sex and race. Results: Greater SBP was associated with lesser ReHo in the bilateral hippocampi, left insula, right lingual, precentral and middle temporal gyri. Greater DBP was associated with lesser ReHo in the bilateral hippocampi, lingual and superior temporal gyri and brainstem and the left temporal pole, right frontal pole and inferior frontal gyrus. Greater DBP was also associated with greater ReHo in the left frontal pole. Conclusions:Greater cumulative BP exposure during young adulthood through midlife is associated with lesser local connectivity in various brain regions linked to cognitive performance, in particular, bilateral hippocampi. The link between BP and hippocampal connectivity is particularly intriguing in the context of established impact of cardiovascular risk factors on Alzheimer’s disease.