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IC‐06‐03: DISTINCT LONGITUDINAL CORTICAL ATROPHY IN NON‐AMNESTIC COMPARED TO AMNESTIC ALZHEIMER'S DISEASE SUGGESTS DIFFERENT PATTERNS OF SPREADING PATHOLOGY
Author(s) -
Da Re Fulvio,
Phillips Jeffrey S.,
Xie Sharon X.,
Ferrarese Carlo,
McMillan Corey T.,
Irwin David J.,
Grossman Murray
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2056
Subject(s) - atrophy , posterior cortical atrophy , pathology , entorhinal cortex , alzheimer's disease , medicine , neuroscience , neocortex , episodic memory , primary progressive aphasia , hippocampus , psychology , disease , frontotemporal dementia , dementia , cognition
labelled vascular water to exchange into brain tissue. Results: The mean cortical exchange time was significantly longer in AQP4 mice (536 6 92ms) relative to WT mice (377 6 89ms) (p 1⁄4 0.004), Figure 1B. This reflects slower movement of vascular water into the extravascular cortical tissue in the absence of AQP4 channels. Table 1 shows no significant difference in cortical arterial arrival time (da), Cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) between animal groups, which indicates preserved cerebral haemodynamics and microstructure. Conclusions:We have developed the first non-invasive imaging technique to assess AQP4-mediated water transport at the brain-blood interface. Previous studies suggest that the capacity of this water transport system is a key determinant of Ab clearance from the brain. The emerging importance of the AQP4mediated clearance pathways, such as the glymphatic system, makes this technique a promising and clinically applicable tool for better understanding the role of AQP4-mediated Ab clearance in AD.