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IC‐06‐02: NON‐INVASIVE IMAGING OF BRAIN CLEARANCE PATHWAYS USING MULTIPLE ECHO TIME ARTERIAL SPIN LABELLING: AN AQUAPORIN‐4 STUDY
Author(s) -
Ohene Yolanda,
Harrison Ian F.,
Nahavandi Payam,
Ismail Ozama,
Ottersen Ole P.,
Nagelhus Erlend A.,
Thomas David L.,
Lythgoe Mark F.,
Wells Jack A.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - Slovenian
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2055
Subject(s) - parenchyma , aquaporin 4 , glymphatic system , medicine , perfusion , perfusion scanning , pathology , clearance , neuroscience , cardiology , biology , urology , cerebrospinal fluid
VOLUMETRIC MEASURES MCI/ Control p[0.57* -0.016 (-.070, .038) p[0.26 0.000 (.00, .00) p[0.31* -0.040 (-. 118, .038) p[0.43 -0.001 (-.002,.001) p[0.38 0.000 (.000,.001) p[0.08 0.001 (.000,.002) Age p[0.009* -0.006 (-.010, -.001) p[0.005 -0.00 (-.00, -.00) p[0.31* -0.003 (-.009, .003) p[0.03 0.000 (.000, -.001) p[0.027 -0.000 (-.000, .000) p[0.035 -0.000 (.00, -.00) Gender p<0.001* 0.091 (.042, .141) p[0.01 0.000 (.00, .00) p1⁄40.75* 0.011 (-.060, .082) p1⁄40.69 0.000 (-.001,.001) p1⁄40.62 0.000 (.000,.001) p1⁄40.28 0.000 (.000,.001) APOE ε4 p1⁄40.86* -0.008 (.006, .012) p1⁄40.63 0.000 (.00,.00) p1⁄40.55 0.024 (-.053, .100) p1⁄40.75 0.000 (-.002,.001) p1⁄40.46 0.000 (.000,.001) p1⁄40.97 -0.000 (-.001,.001) SODIUM MEASURES ** MCI/ Control p<0.001* 0.253 (.126, .381) p<0.001* 0.242 (.107, .377) p<0.001* 0.262 (.142, .381) p<0.001* 0.182 (.090, .274) p<0.001* 0.213 (.101, .325) p[0.003* 0.153 (.053, .254) Age p1⁄40.12* 0.008 (-.002, .018) p1⁄40.60 0.008 (-.008, .013)* p1⁄40.71* 0.002 (-.008, .011) p1⁄40.52* 0.002 (-.005, .010) p1⁄40.27* 0.005 (-.004, .014) p1⁄40.24* 0.005 (-.003, .012) Gender p1⁄40.15* -0.087 (-.205,.032) p1⁄40.17* -0.087 (-.213, .038) p1⁄40.09* -0.097 (-.208,.0 1 5) p1⁄40.12* -0.068 (-.153, .018) p1⁄40.09* -0.091 (-. 195, .013) p1⁄40.13* -0.073 (-.166, .020) APOE ε4 p1⁄40.30* -0.069 (-.197, .060) p1⁄40.54* -0.042 (-.178, .094) p1⁄40.82* -0.014 (-.135, .107) p1⁄40.91* -0.005 (-.098, .088) p1⁄40.72* -0.021 (-.133, .092) p1⁄40.78* -0.015C -.115, .086)