Premium
IC‐02‐05: THE INFLUENCE OF AGE ON REGIONAL [ 18 F]AV‐1451 PET, PITTSBURGH COMPOUND B PET AND MRI ATROPHY IN ATYPICAL ALZHEIMER'S DISEASE
Author(s) -
Whitwell Jennifer L.,
Graff-Radford Jonathan,
Martin Peter R.,
Senjem Matthew L.,
Schwarz Christopher G.,
Spychalla Anthony J.,
Machulda Mary M.,
Weigand Stephen D.,
Drubach Daniel A.,
Jack Clifford R.,
Lowe Val J.,
Josephs Keith A.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2048
Subject(s) - pittsburgh compound b , posterior cingulate , atrophy , nuclear medicine , neuroimaging , precuneus , grey matter , posterior cortical atrophy , medicine , magnetic resonance imaging , standardized uptake value , alzheimer's disease , psychology , white matter , positron emission tomography , neuroscience , cortex (anatomy) , disease , dementia , radiology , cognition
tionship between [18F]AV-1451 uptake and age. Figure 5. Correlated change in regional asymmetry. Note: Repeated measures correlations for regional changes in asymmetry between Ab and tau. Each dot represents one observation (colors reflect subjects), the shape of the symbol indicates the time point (circles for baseline and squares for the follow-up measures) and the lines represent the withinsubject repeated measure correlation fit (under the assumption of random intercept/same slope). Both regions show that EC (rrm1⁄40.28, p1⁄40.018 [0.022, 0.55]) and Temp pole PIB (rrm1⁄40.42, p1⁄40.0003 [0.060, 0.640]) change to a more left-warded asymmetry, which is correlated with the change in tau for these regions. For comparison, we also plotted the change in IT PIB vs tau asymmetry, showing no correlation: IT PIB showed a left-warded bias with time, whereas IT tau shows little change (rrm1⁄4-0.09, p1⁄40.46 [-0.361, 0.265]) Podium Presentations: Saturday, July 21, 2018 P6