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IC‐02‐04: REGIONAL ASYMMETRIES IN AMYLOID AND TAU GO TOGETHER: EVIDENCE FOR LOCAL INTERACTION
Author(s) -
Jacobs Heidi I.L.,
Hanseeuw Bernard J.,
Vannini Patrizia,
Price Julie C.,
Dutta Joyita,
Becker Alex,
Pase Matthew P.,
Satizabal Claudia L.,
Beiser Alexa S.,
Demissie Serkalem,
Daniluk Dan,
Schafer Colin,
Peets Bryanne,
Killiany Ronald,
Sperling Reisa A.,
DeCarli Charlie S.,
Seshadri Sudha,
Johnson Keith A.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2047
Subject(s) - confidence interval , asymmetry , wilcoxon signed rank test , correlation , medicine , psychology , mann–whitney u test , mathematics , physics , geometry , quantum mechanics
data to explore relationships between cortical uptake, age, and nonspecific binding ROIs (nsROIS: thalamus, putamen, pallidum, caudate, and white matter). Mean [F]-AV-1451 ROI values from group 2 were compared to the iron-load distribution in group 3 (VanBergen et al, 2018).Results:Figure 2 shows r for PVC and non-PVC nsROIs. There are two groups of nsROIs, one that is age-related (caudate, putamen, pallidum), and the other composed of white matter and thalamus. We compared non-PVC and PVC correlations between white matter and whole cortex for [C]-PIB and [F]-AV1451 SUVRs. Figure 3 shows white matter correlation with cortex was removed after PVC in [C]-PIB but not in [F]-AV-1451, proving the [F]-AV-1451 correlation stems from non-specific binding in both gray and white matter, not partial volume effects. Figure 4 shows the r between cortical regions and non-specific binding regions in [F]-AV-1451. 67.4% of the variability in whole cortex can be explained by non-specific binding in the putamen and thalamus. Figure 5 shows the mean distribution in older adults of iron regionally co-varies with [F]-AV-1451. Conclusions:There are two types of [F]-AV-1451 non-specific binding in the cortex in HCs. One related to age that best correlates with putamen (possibly explained by iron), the other related to white matter and thalamus. This should be considered when studying the earliest accumulation of tau.