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IC‐02‐02: DISCREPANCIES IN TAU AND β‐AMYLOID BURDEN ARE FREQUENT ACROSS THE SPECTRUM OF NORMAL AGING AND ALZHEIMER'S DISEASE
Author(s) -
Landau Susan M.,
Korman Deniz,
Jagust William J.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2045
Subject(s) - amyloid (mycology) , temporal lobe , alzheimer's disease , psychology , neuroimaging , cognitive impairment , cognition , positron emission tomography , neuroscience , medicine , disease , pathology , epilepsy
the robust associations with age across the population. These results suggest that there are age-related increases in flortaucipir binding already beginning in 30 and 40-year olds. Conclusions: We found significant associations between increasing age and flortaucipir uptake in a population of cognitively normal adults without significant AD pathology. Results in the medial and lateral temporal lobe suggest that flortaucipir is sensitive to primary age-related tau accumulation in middle and older age. The results in the choroid plexus and basal ganglia indicate that previously noted off-target binding in these regions is highly related to biological changes occurring with advancing age. IC-02-02 DISCREPANCIES IN TAU AND b-AMYLOID BURDEN ARE FREQUENTACROSS THE SPECTRUM OF NORMAL AGING AND ALZHEIMER’S DISEASE Susan M. Landau, Deniz Korman, William J. Jagust, University of California Berkeley, Berkeley, CA, USA; University of California Berkeley, Berkeley, CA, USA; Lawrence Berkeley National Laboratory, Berkeley, CA, USA. Contact e-mail: slandau@berkeley.edu