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P1‐200: ANALYSIS OF THE AMYLOID β‐RELATED PEPTIDES IN MOUSE PLASMA AND CELL CULTURE MEDIA
Author(s) -
Kaneko Naoki,
Matsuzaki Masaya,
Yoshizawa Yota,
Iwamoto Shinichi,
Tanaka Koichi,
Tomita Taisuke
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.204
Subject(s) - cell culture , chemistry , microbiology and biotechnology , neuroblastoma , peptide , amyloid (mycology) , biochemistry , biology , inorganic chemistry , genetics
attainment was 14.68 (2.8) years. Diet was assessed annually using a comprehensive food frequency questionnaire (FFQ). The last FFQ collected was on average 5.9 years before death. Autopsied brains were analyzed to quantify in multiple brain regions, b-amyloid plaques and tau tangle density, neocortical Lewy bodies, hippocampal sclerosis, gross and microscopic cerebral infarcts, cerebral atherosclerosis and arteriosclerosis. Summary measures of neurodegenerative pathologies were computed based on published criteria: NIAReagan score (low, intermediate, high AD pathology), Braak stage (neurofibrillary tangle stage I – VI), CERAD score (neuritic plaque severity). Linear and logistic regression models were used to assess the cross-sectional associations of the western diet pattern with brain neuropathologies. Results: In models adjusted for age, sex and education, the more consistent the diet pattern to the Western diet, defined as highest tertile of intake versus lowest, was significantly associated with more AD pathology including greater neuritic plaque severity (CERAD score) (b 1⁄4 0.33 (SE1⁄40.13, p1⁄40.01), higher NIA-Reagan scores (B1⁄40.16, SE1⁄40.08, p1⁄40.05), and higher amyloid level [b1⁄4 0.64 (SE1⁄40.26, p1⁄40.01). Higher scores of the Western diet were also associated with higher probability of arteriolosclerosis [OR1⁄41.31 (95% CI1⁄4 1.04, 1.64)]. Conclusions: In cross-sectional analyses, the Western dietary pattern was associated with more severe Alzheimer disease neuropathologic changes, specifically amyloid levels, neuritic plaques, and with small vessel disease.