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P1‐199: WESTERN DIET IS RELATED TO AD AND VASCULAR BRAIN NEUROPATHOLOGIES IN OLDER ADULTS
Author(s) -
Aggarwal Neelum T.,
Schneider Julie A.,
Holland Thomas,
Wang Yamin,
Cherian Laurel J.,
Morris Martha Clare
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.203
Subject(s) - cohort , medicine , dementia , senile plaques , cognitive decline , brain aging , alzheimer's disease , disease , pathology , gerontology
membrane and eventually disrupting cellular well-being in time. Once the mapping of the size and shape conformations of the oligomers is completed, the neurons will be cultured on clean glass and incubated with fluorescently tagged Ab oligomers at various pHs, concentrations and salt solutions. The following stage of this research is to use fluorescent microscopy to image and map the interaction of Alzheimer’s Disease Ab oligomers at various stages of oligomerization, stages dictated by the incubation conditions, with neurons. Conclusions: Quantifying the neuronal cells viability in the presence of specific populations of Ab oligomers can narrow the size of the toxic oligomers and knowing the conditions that favor these populations can constitute an important stage in developing a hypothesis of the mechanism at the basis of Alzheimer’s Disease and a good starting point for developing a cure.