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P1‐197: AMYLOID BETA EFFECTS ON INSULIN PERMEABILITY FROM PLASMA TO BRAIN MEASURED BY I‐125 INSULIN SPECT IN APP/PS1 MICE
Author(s) -
Swaminathan Suresh K.,
Min Hoon-Ki,
Sarma Vidur V.,
Ahlschwede Kristen M.,
Bruinsma Tyler J.,
Curran Geoffry L.,
Decklever Teresa,
Lowe Val J.,
Kandimalla Karunya K.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.201
Subject(s) - insulin resistance , insulin , medicine , blood–brain barrier , endocrinology , amyloid beta , genetically modified mouse , pathogenesis , insulin receptor , diabetes mellitus , transgene , biology , disease , central nervous system , biochemistry , gene
verify the expression changes of these enzymes, qRT-PCR assays for each enzyme were performed. Results: There is a significant expression increase of the enzymes; BACE, ADAM 9, PRES2 and a reduction of ADAM 10 in retina, Optic nerve (O.N.) and Visual cortex (V.C.) on aged mice as well as on 3xTg-AD mice. Conclusions: The increase of the enzymes involved in the amyloidogenic pathway in the retina, O.N. and V.C., suggest that ßA42 accumulation on these regions is a consequence of the over activation of this pathway in normal aging and AD. These changes could be associated to the visual loss function observed in AD patients.