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P3‐614: VASCULAR DEMENTIA AND DIETARY PATTERN: A SUBPOPULATION ANALYSIS OF THE ADVENTIST HEALTH STUDY‐2
Author(s) -
Perez Lisandra Guzman,
Sherzai Ayesha Z.,
Knutsen Synnove,
Sherzai Dean
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1981
Subject(s) - medicine , gerontology , biopsychosocial model , cohort , demography , psychology , psychiatry , sociology
Background:The objective of this study is to investigate the association between dietary patterns (vegan, lacto-ovo, pesco-vegetarian, semi-vegetarian and non-vegetarian) and cognitive status among the Biopsychosocial Religion and Health Study (BRHS), a subset of the Adventist Health Study-2 (AHS-2). Methods: The cohort comprises 508 BRHS members residing in Southern California. A cross-sectional analysis was performed on all 508 subjects who completed both, the AHS-2 questionnaire focusing on nutrition and a questionnaire containing many previously validated measures of religion, lifestyle, emotional wellbeing and nutrition. Subjects reported their consumption frequency of red meat, fish, eggs, and dairy products over the past 12 months. Cognitive status was measured by the short standardized version of the California Verbal Learning Test (CVLT) was administered to all study participants in this study, which is a verbal list-learning measure designed to evaluate multiple components of memory. The CVLT performance was reported as a summary Tscore, reflecting level of immediate recall over the five successive trials of the first list, with higher scores reflecting better performance. The purpose of this analysis was to use a best-fit model to determine the relationship between dietary pattern and cognitive status. Results: The mean age of this group was 72 years old (40-106 years old), significantly more females. The majority of the participants were non-vegetarians and lactoovo vegetarian: 39% non-vegetarian, 34% lacto-ovo vegetarian, 12% pesco-vegetarian, 8% semi-vegetarian, and 7% vegan. A factor analysis and a stepwise regression were run to identify any relationships between cognition and specific dietary subtypes, controlling for gender, education, and depression. The results supported a three-factor model comprised of Recall Memory, Passive/ Discrimination Learner, and Active Learner. The results are interpreted as variance inflation factor (VIF). Our analysis indicated a high association of Lacto-ovo vegetarian dietary with Recall Memory factor and Learning Strategy factor. No significance was observed for other dietary factors. Conclusions:A lacto-ovo vegetarian dietary pattern was associated with better subscores of the CVLT, namely Recall Memory factor and Learning Strategy factor scores. Our findings should be interpreted with caution given the intrinsic limitation of a cross-sectional design. Robust longitudinal studies are needed to draw more conclusive outcomes.