Premium
P3‐594: RELATIONSHIP BETWEEN APOLIPOPROTEIN‐ε4 AND COGNITIVE DECLINE AND THE MODERATING EFFECTS OF AGE, SEX, AND ETHNICITY: THE COSMIC COLLABORATION
Author(s) -
Makkar Steve R.,
Lipnicki Darren M.,
Crawford John D.,
Thalamuthu Anbupalam,
Kochan Nicole A.,
Brodaty Henry,
Sachdev Perminder S.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1960
Subject(s) - cognitive decline , cognition , confounding , demography , ethnic group , psychology , effects of sleep deprivation on cognitive performance , apolipoprotein e , association (psychology) , gerontology , medicine , dementia , psychiatry , disease , sociology , anthropology , psychotherapist
variables, comorbid conditions and APOE ε4 carrier status. Results: Participants included in this analysis had mean age of 74.6 (SD1⁄46.0), 69.6% were women. A total of 87 participants were diagnosed with dementia during the study follow-up. 150 participants (15.7%) were on metformin. Metformin use was associated with increased risk of incident dementia (hazard ratio1⁄42.28, p1⁄40.0152) after adjusting for age, gender, education, body mass index, and APOE status. Metformin use was also associated with more diabetes complications (odds ratio1⁄4 1.47, p1⁄40.0168). Further adjusting for comorbid conditions and diabetes complications did not change the significant association between metformin use and increased dementia risk. Conclusions:There was a significant association between metformin use and increased risk of incident dementia in African American participants with diabetes. Further research is needed to determine the factors underlying this associ-