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P3‐579: ASSOCIATION OF APOLIPOPROTEINS AND APOLIPOPROTEIN SUBSPECIES WITH HIPPOCAMPAL AND WHITE MATTER LESION VOLUME
Author(s) -
Koch Manja,
DeKosky Steve,
Fitzpatrick Annette L.,
Furtado Jeremy D.,
Lopez Oscar L.,
Kuller Lewis H.,
Mackey Rachel H.,
Hughes Timothy M.,
Mukamal Kenneth J.,
Jensen Majken K.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1945
Subject(s) - white matter , hippocampal formation , apolipoprotein e , lesion , subspecies , hyperintensity , medicine , brain size , pathology , magnetic resonance imaging , alzheimer's disease , psychology , biology , disease , zoology , radiology
global cognition (p1⁄40.01), verbal memory (p1⁄40.03), visuospatial function (p1⁄40.004), and attention-processing speed (p1⁄40.04). Higher adherence to DP4 was associated with poorer verbal memory (p1⁄40.02). No associations were observed for DP1. T2D did not modify any associations (p>0.05 for interaction). The addition of T2D to the models reduced the strength of the association by 20% for the relationship between of DP3 with visuospatial function (30%), and for DP2 with visuospatial function (50%) and grey matter volume (20%), such that associations were no longer significant. In contrast there was little change in the co-efficient for T2D with andwithout DP in these model (<5%).Conclusions:DP are linked to poorer cognition, but different unhealthy patterns have differing effects on cognitive domains. T2D may be a partial mediator, but this needs exploring in longitudinal studies.