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P3‐577: RISK FACTORS FOR DEMENTIA IN 55‐75‐YEAR‐OLDS ENROLLED IN A PILOT STUDY FOR MAINTAIN YOUR BRAIN, AN INTERNET PREVENTATIVE INTERVENTION
Author(s) -
Heffernan Megan,
Andrews Gavin,
Anstey Kaarin J.,
Fiatarone Singh Maria A.,
Jorm Louisa,
Maeder Anthony,
McNeil John,
Lautenschlager Nicola T.,
Sachdev Perminder S.,
Valenzuela Michael,
Brodaty Henry
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1943
Subject(s) - mood , medicine , dementia , anxiety , depression (economics) , psychological intervention , gerontology , cognition , intervention (counseling) , clinical psychology , disease , psychiatry , economics , macroeconomics
functioning. Notably, living in urban areas has been linked to lower risk of dementia. However, findings are mixed and come predominantly from higher-income countries. We examined the association of place of birth and place of residence (urban versus rural) at older age (65 and above) with cognitive functioning in a communitydwelling cohort of older adults in Lebanon (n1⁄4475; age1⁄472.50 (SD1⁄47.22); 56% women). Methods: Cognitive scores were measured using the Community Screening Instrument for Dementia (CSI-D) and Rowland Universal Dementia Assessment Scale (RUDAS). We used linear regression models, adjusted for important covariates, to assess the separate and joint associations of place of birth and residence as well as change in urban living with cognitive scores. Results: In our sample, 59% were born and 64% currently lived in urban areas; 79% of those born in urban areas also lived in urban areas at older age. Being born and residing in urban areas were each associated with lower cognitive scores (beta1⁄41.39 (95% CI1⁄4-1.86,-0.92) CSI-D and -2.13 (95% CI1⁄4-2.88,-1.38) RUDAS scores) and (beta1⁄4-1.67 (95% CI1⁄4-2.15,-1.20) CSI-D and -2.8 95% CI1⁄4-3.55,-2.07 RUDAS scores), respectively. When mutually adjusted for each other, both being born and currently residing in a city were associated with additional lower cognitive scores. Analyses examining change in living settings showed that, compared to participants born and currently residing in rural areas, those who moved (either from urban place of birth to rural residence and vice versa) were not different in their cognitive scores, but, participants born and residing in urban areas had lower cognitive scores. Urban place of birth and residence were associated with higher odds of having cognitive impairment and decline based on the cognitive scores. Further adjustment for lifestyle and medical confounders did not alter results. Conclusions:Results suggest important differences in cognitive functioning related to living conditions among Lebanese older adults. Unlike some findings in higher-income countries, being born and residing at older age in urban settings in Lebanon –which potentially entails more exposure to stress, crowdedness, and pollution– is associated with poorer cognitive functioning.