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P3‐561: ADHERENCE TO THE MIND DIET IS ASSOCIATED WITH BETTER COGNITION IN THE FRAMINGHAM HEART STUDY
Author(s) -
Himali Jayandra J.,
Melo van Lent Debora,
O'Donnell Adrienne,
Jacques Paul F.,
Wagner Michael,
Vasan Ramachandran S.,
Beiser Alexa S.,
Seshadri Sudha,
Pase Matthew P.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1927
Subject(s) - medicine , cognition , dementia , framingham risk score , framingham heart study , neuropsychology , cognitive decline , cohort , episodic memory , effects of sleep deprivation on cognitive performance , dash , disease , gerontology , psychiatry , computer science , operating system
cognitive decline in MCI and AD subjects. Most common NSAIDs did not alter cognitive decline. However, diclofenac use correlated with slowed cognitive deterioration, providing exciting evidence for a potential disease modifying therapeutic. Conversely, paracetamol use correlated with accelerated decline; which, if confirmed to be causative, would have massive ramifications for the recommended use of this prolific drug. p1⁄4.46 p1⁄4.27 Cognition (Working memory) F (2, 401) 1⁄4 1.78, p1⁄4.17 F (2, 156) 1⁄4 3.25, p1⁄4.04 Physical functioning F (2, 384) 1⁄4 7.11, F (2, 138)1⁄43.49, P3-560 THE INTERPLAY BETWEEN BASELINE p<.001 p1⁄4.03 PPA/comorbidites F (2, 364) 1⁄4 1.12, p1⁄4.33 F (2, 117) 1⁄4 2.53, p1⁄4.08 COGNITIVE STATUS AND FALLS HISTORY ON CHANGES IN MEMORYAND PHYSICAL FUNCTION AMONG OLDER ADULTS: A 1-YEAR PROSPECTIVE COHORT STUDY