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P3‐554: PROFILE OF MILD BEHAVIOURAL IMPAIRMENT IN A POPULATION‐BASED SAMPLE OF ADULTS AGED 50 AND OVER: INITIAL FINDINGS FROM THE PROTECT STUDY
Author(s) -
Creese Byron,
Brooker Helen,
Ismail Zahinoor,
Aarsland Dag,
Corbett Anne,
Khan Zunera,
Megalogeni Maria,
Ballard Clive,
Wesnes Keith
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1920
Subject(s) - checklist , dementia , mood , psychology , clinical psychology , anxiety , cognitive impairment , psychosis , population , cognition , psychiatry , medicine , disease , environmental health , cognitive psychology
onset of “cognitive pathology” defined as incidence of accelerated declines commonly believed to be indicative of ADRD pathology. Methods:Analyses used data from a nationally representative prospective cohort study (N1⁄429,262) of U.S. residents to jointly model “healthy aging” versus “pathological decline”. Longitudinal models layered Cox proportional hazards models over longitudinal mixed-effects model to jointly model cognitive aging and incidence of cognitive pathology. Life-expectancy ratios (LER) and 95% confidence intervals were reported. Results:Results replicated a host of research showing that education was associated with improved lifetime cognition. Uniquely to this study, results also revealed that higher education was associated with later onset of cognitive pathology (LER1⁄41.042 95% CI1⁄4[1.041-1.043]). Supporting cognitive reserve research, results also revealed a significant association with more rapid declines after onset of acceleration. Conclusions:This study supports earlier work showing that education does not result in faster rates of healthy cognitive aging, but nevertheless also revealed that education was associated with the length of time spent without cognitive pathology. Results therefore support cognitive reserve theory.