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P3‐494: EXAMINING THE INFLUENCE OF UNDETECTED ATN NEUROPATHOLOGY ON COGNITIVE AGING TRAJECTORIES
Author(s) -
Harrington Karra D.,
Hassenstab Jason,
Maruff Paul,
Masters Colin L.,
Aschenbrenner Andrew J.,
Fagan Anne M.,
Benzinger Tammie L.S.,
Cruchaga Carlos,
Morris John C.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1858
Subject(s) - neuropathology , episodic memory , cognitive decline , dementia , psychology , biomarker , semantic memory , cognition , neuropsychology , clinical dementia rating , medicine , neuroscience , gerontology , disease , cognitive impairment , biology , biochemistry
Second, a longitudinal analysis was performed to evaluate intrasubject difference between visits.Results:The result revealed differential aging and education effects on lexical performance across tasks. The cross-sectional analysis showed that age significantly predicted the performance on BNT & Semantic Fluency Test. This indicates that older elderly performed poorly than younger elderly at these tasks. Longitudinally, the year of education only significantly predicted the accuracy decline on Vocabulary and Semantic Fluency but not the accuracy changes on BNT and Phonemic Fluency Test. Participants with fewer years of education showed more decline on the accuracy of these tests. It suggests that individuals with higher education better compensate their lexical ability decline on selective tasks.Conclusions:The education effect on lexical production tasks is not the same across tasks and amount of education plays different roles in cognitive reserve. This effect has to be considered in identification of early cognitive changes in healthy elderly or people with pre-dementia phase.