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P3‐471: LANGUAGE IMPAIRMENT IN PROGRESSIVE SUPRANUCLEAR PALSY AND CORTICOBASAL SYNDROME
Author(s) -
Peterson Katie A.,
Patel Nikil,
Barrick Thomas Richard,
Cappa Stefano F.,
Patterson Karalyn,
Rowe James B.,
Garrard Peter
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1835
Subject(s) - progressive supranuclear palsy , corticobasal degeneration , aphasia , primary progressive aphasia , psychology , audiology , differential diagnosis , cognition , language impairment , medical diagnosis , medicine , physical medicine and rehabilitation , developmental psychology , cognitive psychology , psychiatry , pathology , disease , dementia , frontotemporal dementia
(AIBL) study underwent four assessments using a computerised paired associate learning task (CPAL) over a period of 54 months. Results: At baseline, there was no significant group difference in PAL performance over the trials of the CPAL. However, a significant group x time interaction effect was observed over the 54month study period, with the AbCN group, but not the Ab+ CN group, evidencing improvement in PAL performance, F (1, 703.08) 1⁄4 4.73, p 1⁄4 .03, Cohen’s d 0.39 [0.04, 0.75]. Conclusions: Results suggest that the CPAL is sensitive to detecting reductions in PAL over time, but not at baseline, in Ab+ CN older adults. Importantly, this indicates a lack of benefit from repeated exposure to the task over time associated with Ab+, which is not the case for AbCNs. Further, results indicate that assessing change in Ab+ related cognition over time, rather than at a single assessment, provides greater understanding of dysfunction in this early stage of disease.