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P3‐466: THE HEALTHY BRAIN PROJECT: STUDY METHODOLOGY AND BASELINE CHARACTERISTICS OF AN ONLINE STUDY OF 3,400 MIDDLE‐AGED ADULTS
Author(s) -
Buckley Rachel F.,
Bransby Lisa,
Properzi Michael J.,
Yassi Nawaf,
Lim Yen
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1830
Subject(s) - dementia , cognition , gerontology , session (web analytics) , cognitive decline , population , medicine , cognitive impairment , age limit , psychology , baseline (sea) , demography , psychiatry , disease , computer science , environmental health , oceanography , pathology , sociology , world wide web , geology
open field test (OFT) were assessed at 4 and 12-mo. Results:2xTg-AD mice exhibited earlier onset of age-associated increase in aortic stiffness vs. WT mice (Fig. 1). SBP increased with age in both genotypes, and 2xTg-AD mice had higher SBP at 12-mo compared to WT mice (Fig. 2). No differences in cardiac dimensions or functionwere evident between 2xTg-AD mice and WT mice at 4-mo. But at 12-mo there was an increase in left ventricle (LV) posterior wall thickness (LVPW), and narrowed LV internal diameter (LVID) in 2xTg-AD vs.WTmice. LV hypertrophy in 12-mo 2xTg-ADmicewas accompanied by lower LV volumes (LV-Vol), greater ejection fraction (EF) and fraction shortening (FS) vs. age-matched WTmice (Table). 2xTg-AD mice exhibited impaired spatial learning and memory in the MWM at both 4 and 12-mo vs. age-matched WT (Fig. 3, 4). 12-mo 2xTg-AD mice had a trend for lower scores in NBT and lower vertical activity in the OFT (Fig. 5) vs. 12-mo WT mice. Conclusions: 2xTg-AD mice, unlike age-matched non-transgenic counterparts, exhibit early onset of cardiovascular abnormalities that are evident only after the onset of amyloid accumulation and cognitive impairment. If and how amyloid accumulation in neurons adversely affects the cardiovascular system remain to be determined. Supported by the NIH/NIA Intramural Research Program.