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P3‐462: A COMPLICATED CASE OF HERNS
Author(s) -
Yu Yingxin
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1826
Subject(s) - medicine , weakness , retinopathy , magnetic resonance imaging , stroke (engine) , lesion , ventricle , fluid attenuated inversion recovery , pathological , pathology , radiology , surgery , diabetes mellitus , mechanical engineering , engineering , endocrinology
findings showed a decrease in LC3 and Beclin-1 in GRN mutation cases in the subiculum and temporal grey matter respectively compared to controls. There were no significant changes in CMA markers in these regions. In the frontal lobe, LC3 immunoreactivity was decreased in Layer VI of the grey matter in all three FTD mutation groups compared to controls with MAPT cases also demonstrating a significant decrease in LC3 staining in frontal white matter. Conclusions: These findings suggest a regional variation in recruitment of autophagy pathways between normal-ageing and FTD associated genotypes. Future work will include western blot, immunofluorescence analysis and expansion of the cohort to include 64 FTD cases and 11 controls.