P3‐449: THE APOLIPOPROTEIN E GENE AFFECTS THE DEFAULT MODE NETWORK ACROSS THE ALZHEIMER'S DISEASE SPECTRUM

the male, statistically significant predictors (p<0.05) were DG, age, and interaction of DG and age (Fig 1a, b). For HV in the female, significant variables were DG, age, and interaction of DG and age (Fig 2a). For HV/eTIV in the female, significant variables were DG and age, while the interaction of DG and age was not significant (Fig2b). In addition, significant factors on eTIV were sex (Male>Female) and the interaction of age and sex in NC. Conclusions: The common finding in male and female in J-ADNI was that the difference in HV between NC and mADD was smaller in older elderly subjects, leading to lowered detectability of HV loss due to AD. However, as the age-related decline of eTIV was a little bit steeper in female than in male, HV/eTIVof NC and mADD did not get on closer in older elderly subjects compared to HV.