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P3‐448: THE EFFECT OF AGE AND SEX ON EVALUATION OF HIPPOCAMPAL ATROPHY IN NORMAL AND MILD ALZHEIMER'S DISEASE DEMENTIA: A J‐ADNI STUDY
Author(s) -
Okada Yusuke,
Iwata Kaori,
Kato Takashi,
Kimura Yasuyuki,
Kizawa Go,
Nakamura Akinori,
Hattori Hideyuki,
Toyama Hiroshi,
Matsuda Hiroshi,
Ito Kengo,
Iwatsubo Takeshi
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1811
Subject(s) - dementia , alzheimer's disease neuroimaging initiative , neuroimaging , atrophy , medicine , hippocampal formation , disease , hippocampus , psychology , pediatrics , psychiatry
intrinsic brain activity reflected by ALFF/fALFF levels were detected in SCD, aMCI and d-AD. As disease progressed, the number of brain regions with changed ALFF/fALFF levels was increasing and the extent of disturbances get heavier. In SCD, the ALFF/ fALFF levels of frontal lobe were positively correlated with the neurophysiological tests. Decreased ALFF/fALFF levels in brain regions closely related to impaired episodic memory were found in aMCI and d-AD. Conclusions:Our study may indicate continuous breakdown of spontaneous brain activity during the disease progression of AD. The ALFF/fALFF changes can characterize the physiology of AD and may potentially provide implications for AD therapeutics.