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P3‐445: FACTORS PREDICTING MORTALITY AT THE MEMORY CLINIC AT SIRIRAJ HOSPITAL: 815 THAI COHORT
Author(s) -
Kate Mara,
Chaewwit Pipat,
Rattanabannakit Chatchawan,
Hunnangkul Saowalak,
Aoonkaew Nutthapol,
Chaichanettee Sunisa,
Scheltens Philip
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1808
Subject(s) - medicine , cohort , memory clinic , comorbidity , dementia , depression (economics) , cohort study , pediatrics , disease , economics , macroeconomics
fasting blood glucose levels. Conclusions:Female sex is a risk factor for development of dementia for reasons that are incompletely understood. Verbal memory performance is higher in women than men, as is metabolism within the frontal and medial temporal regions involved in mediating it. Both medial temporal and Broca’s areas tended to metabolically decline faster in women with MCI than in men, and that decline in women (but not men) was accelerated by higher fasting blood glucose levels. The observed changes in regional cerebral metabolism may thus point to exacerbating interactions between known risk factors for Alzheimer’s disease development, and the possibility that maintaining normoglycemic status may be of particular benefit among women with elevated risk for developing dementia.