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P3‐442: CEREBRAL GABA, RESTING‐STATE FUNCTIONAL CONNECTIVITY AND MEMORY FUNCTION IN ALZHEIMER'S DISEASE
Author(s) -
Köbe Theresa,
Wang Hui,
Göschel Laura,
Aydin Semiha,
Ittermann Bernd,
Flöel Agnes,
Fillmer Ariane
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1805
Subject(s) - default mode network , recall , posterior cingulate , resting state fmri , cognition , neuroscience , hippocampus , episodic memory , functional connectivity , cognitive impairment , functional magnetic resonance imaging , medicine , disease , magnetic resonance imaging , psychology , audiology , cognitive psychology , radiology
might possibly play a role in these deficits, the underlying mechanism of how these NFT formations affect this cognitive domain remains unclear. Here we propose to identify the brain regions with NFT deposits that contribute to the cognitive decline across the AD spectrum. Methods: [F]AV1451 images of 93 cognitively normal (CN), 66 mild cognitive impairment (MCI) and 16 Alzheimer’s disease (AD) was acquired from the ADNI cohort with their corresponding demographic information and logical memory immediate recall and delayed recall subscores. SUVr images were created using cerebellum grey matter as the reference region. Lasso regularized regression was performed in each diagnosis group using 46 ROIs to identify the 10 most contributing brain regions for the decline in immediate recall and delayed recall separately. 50, 000 bootstrap runs were performed to remove bias introduced by the outliers in the dataset. Using the identified brain regions (10) lasso regularized regression was performed to identify the effect of regional TAU deposition to the cognitive measures. Results: In CN stage, TAU deposition in the right lingual gyrus, right parahippocampal gyrus and bilateral hippocampus are associated with the decline in both immediate and delayed recall cognitive measures. In the MCI stage, TAU deposition in bilateral parahippocampai is associated with the decline in immediate recall, whereas the TAU deposition in bilateral parahippocampai and left hippocampus is associated with the decline in delayed recall. In the AD stage, TAU deposits in the right angular gyrus is associated with the decline in immediate recall whereas TAU deposition in right superior parietal gyrus is associated with the decline in delayed recall. [Figure 1, 2] Conclusions: These results support a framework in which logical memory deficits are a consequence of TAU deposition in a network of regions rather than in independent discrete brain regions serving memory and language.