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P3‐435: WIDESPREAD BRAIN CHANGES EVIDENT IN ALZHEIMER'S DISEASE WHEN MEASURED WITH HIGH‐PERFORMANCE MACHINE‐LEARNING SOFTWARE
Author(s) -
Pierson Ronald
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1798
Subject(s) - putamen , temporal lobe , thalamus , psychology , amygdala , neuroscience , atrophy , hippocampus , lateral ventricles , brain morphometry , alzheimer's disease , neuroimaging , medicine , magnetic resonance imaging , disease , radiology , epilepsy
original definition, encompassing brain pathology, demographics and genetic factors. Neural substrates of CR from the perspective of network topologies and functional connectivity were examined. Methods: Total 79 AD spectrum subjects underwent 3D T1weighted, resting-state fMRI, and tau (THK-5351) and amyloid (Florbetaben) PET. We hypothesized CR as a residual of actual cognitive performance and expected performance from the pathology, demographics and genetic factor. Then, we validated this measure using education as a typical CR proxy. We performed graph analysis to investigate the association between different level of network characteristics and our CR marker. Results: Higher CR was associated with a greater nodal strength, nodal clustering coefficient and local efficiency of Rt. middle temporal pole. One cluster of edges centered on the Rt. middle temporal pole as persistent cluster significantly correlated with CR. CR had association with the interhemispheric functional connectivity between Lt. frontoinsular and Rt. temporal lobes. Conclusions:This study demonstrated that Rt. middle temporal pole could be a center for neural substrates associated with CR. In addition, strong inter-hemispheric connection between Lt. frontoinsular and Rt. temporal lobes may provide an underlying basis for CR. Multimodal imaging and network perspectives can help give insight into the research about CR.