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P3‐421: DISRUPTED FUNCTIONAL CONNECTIVITY OF CORNU AMMONIS SUBREGIONS IN MILD COGNITIVE IMPAIRMENT: A LONGITUDINAL RESTING‐STATE FMRI STUDY
Author(s) -
Li Hui,
Li Kuncheng
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1784
Subject(s) - neuropsychology , hippocampal formation , resting state fmri , functional connectivity , neuroscience , psychology , cognitive impairment , medicine , hippocampus , superior frontal gyrus , cognition , episodic memory , audiology , cardiology
temporal lobe and parietal lobe may occur prior to those in the hippocampus and entorhinal cortex (Insel et al., 2015). This suggests that the accepted event sequence may need to be revised using better biomarkers of regional atrophy. Methods: We used CSF and structural MRI data from the Alzheimer’s Disease Neuroimaging (ADNI) dataset, restricting our analysis to 732 images from 204 APOE+ (at least one APOE4 allele) subjects: 22 healthy, 120 MCI and 62 Alzheimer’s subjects. We used a recently developed parametric Bayesian multi-task learning based longitudinal trajectory model, applying it to model twenty cortical ROI volumes parcellated via GIF (Cardoso et al., 2015). The model robustly estimates intercepts and slopes for each subject by sharing information across subjects. We used the slope estimates from these models as biomarkers of regional brain atrophy and built an event-based model (EBM) as in Young et al., (2014), which included CSF measures and brain structure measures at baseline. To reduce the number of biomarkers, we selected the regional slope and baseline biomarkers that had a minimum eta-squared effect size of 0.2 between healthy and Alzheimer’s disease groups. We compared our results to an event-based model built using ordinary least squares (OLS) based estimates of regional rates of change. Results: The top EBM in Figure 1, which uses OLS slopes, is in close agreement with Young et al., (2014). The bottom EBM, which uses multi-task learning based slopes, shows abnormalities within the temporal, parietal, frontal and insula occurring alongside changes in CSF phosphorylated and total tau. Conclusions:Changes in regional volumes may co-occur with changes in CSF proteins, predating changes within the medial-temporal lobe. References: Cardoso, M.J., et al. 2015. IEEE TMI Insel, P.S., et al., 2015. Alzheimers Dementia Jack, C.R., et al., 2010. Lancet Neurology Young, A.L., et al. 2014. Brain.