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P3‐420: AN EVENT BASED MODEL OF ALZHEIMER'S DISEASE IN APOE+ SUBJECTS USING ROBUST BIOMARKERS OF VOLUMETRIC CHANGE IN REGIONAL BRAIN STRUCTURE
Author(s) -
Aksman Leon M.,
Firth Nicholas,
Scelsi Marzia Antonella,
Schott Jonathan M.,
Ourselin Sebastien,
Altmann Andre
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1783
Subject(s) - entorhinal cortex , atrophy , alzheimer's disease neuroimaging initiative , temporal lobe , statistical parametric mapping , neuroimaging , psychology , neuroscience , medicine , alzheimer's disease , disease , magnetic resonance imaging , hippocampus , radiology , epilepsy
thresholded and convolved with a Gaussian kernel to match the PET camera resolution. PVC was performed according to the M€ueller-G€artner and Meltzer approaches. Composite SUVR was computed using a grouping of four larger cortical regions, equally weighted, with subcortical white (SWM) or cerebellar grey (CGM) matter as reference regions. Results: Strong correlation was observed between PVC2 and no PVC SUVR values normalized to SWM uptake (r21⁄40.94). PVC2 SUVRs were significantly higher than no PVC SUVRs (P<0.001). A Bland-Altman plot revealed proportional bias between PVC2 and no PVC SUVRs: bias increased with higher SUVRs. Repeated measures ANOVA showed that PVC3 SUVRs were higher than PVC2 and no PVC, and PVC2 SUVRs were higher than no PVC (all tests P<0.0001). SUVRs were normalized to CGM uptake. Conclusions:Despite strong correlation between partial volume corrected and uncorrected SUVR values, they are not merely interchangeable. At higher SUVR values PVC2 tends to have a larger effect, plausibly related to the amount of atrophy. P3-420 AN EVENT BASED MODEL OF ALZHEIMER’S DISEASE IN APOE+ SUBJECTS USING ROBUST BIOMARKERS OF VOLUMETRIC CHANGE IN REGIONAL BRAIN STRUCTURE Leon M. Aksman, Nicholas Firth, Marzia Antonella Scelsi, Jonathan M. Schott, Sebastien Ourselin, Andre Altmann, Centre for Medical Image Computing, University College London, London, United Kingdom; Centre for Medical Image Computing, University College London, London, United Kingdom; Translational Imaging Group, Centre for Medical Image Computing, University College London, London, United Kingdom; Dementia ResearchCentre, UCL Institute of Neurology, London, United Kingdom. Contact e-mail: l.aksman@ucl.ac.uk