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P3‐407: PATTERN OF CORTICAL THINNING AND SHAPE VARIABILITY RELATED TO ALZHEIMER'S DISEASE IN REGIONS AFFECTED BY EARLIEST NEUROFIBRILLARY TANGLE PATHOLOGY
Author(s) -
Xie Long,
Wisse Laura,
Das Sandhitsu R.,
Ittyerah Ranjit,
Yushkevich Paul A.,
Wolk David A.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1770
Subject(s) - neurofibrillary tangle , temporal lobe , entorhinal cortex , tangle , neuroscience , alzheimer's disease , pathology , superior temporal sulcus , anatomy , psychology , hippocampus , medicine , senile plaques , disease , epilepsy , mathematics , perception , pure mathematics
Figure 1. (A) The progression of neurofibrillary tangle (NFT) pathology in the medial temporal lobe in Braak stages I and II. Braak stages III-VI are not shown. NFT pathology starts in trans-entorhinal area (lateral ERC/BA35) and precedes to the ERC and the hippocampus. (B) The two dominant anatomical variants of the medial temporal lobe, defined by the folding patterns of the collateral sulcus (CS). Variant 1 has deep and continuous CS while variant 2 has discontinuous CS. Figure adapted from (Xie et al., 2017; Braak and Braak, 1995; Ding and Van Hosesen, 2010). Fulvio Da Re, Jeffrey S. Phillips, Sharon X. Xie, Carlo Ferrarese, Corey T.McMillan, David J. Irwin, MurrayGrossman, University of Milano-Bicocca, Milan, Italy; School of Medicine and Surgery, Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy; Penn Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Contact e-mail: dare.fulvio@gmail. com